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Changelog

Follow up on the latest improvements andย updates.

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new

models

๐Ÿ”ท New Model Release: DIAMOND

Weโ€™ve added
DIAMOND
, a fast and efficient protein structure search model built for large-scale discovery workflows. DIAMOND enables high-throughput structural comparisons with strong accuracy, making it well-suited for iterative design loops and database-scale similarity search.
Highlights
  • Ultra-fast structural search at scale
  • Designed for proteome- and library-level comparisons
  • Initial database includes USPTO, with more to come!
  • Use it to screen designed molecules to make sure they're not patented already.
Check it out here: https://biolm.ai/models/diamond/
carbon (2)

new

models

๐Ÿง  New Model Releases

We've expanded our model collection with three additions focused on protein stability and molecular interaction modeling.
๐Ÿ•’ TemBERTure GitHub โ†’
Predicts
protein thermostability class
and
melting temperature (Tm)
using sequence data from thermophilic and non-thermophilic organisms.
๐ŸŒ SPURS GitHub โ†’
Predicts
ฮ”ฮ”G stability changes
from mutations and helps identify
functionally important protein sites
.
โšก Boltz-2 GitHub โ†’
Predicts
3D proteinโ€“ligand structures
and
binding affinities
, enabling fast, large-scale molecular screening.
---
All three models are now available
to use within the platform.

new

console

protocols

๐Ÿงฌ Introducing Protocols: Reproducible AI Workflows for Molecular Design

Protocols
are reproducible, end-to-end workflows that define how BioLM models and tools work together to achieve a design goal. Think of them as
experiment blueprints
: structured, versioned, and repeatable.
Whatโ€™s New
  • ๐Ÿงช
    Protocols Tab:
    A new home in Console for running and managing your workflows.
  • ๐Ÿ’ก
    Built-In Protocols:
    Start with
    AntiFold Design Antibodies
    , an end-to-end pipeline for generating and scoring antibody variants.
  • โš™๏ธ
    Custom Protocols:
    Define your own protocol logic using a simple YAML schema โ€” including input parameters, batch limits, and Pub/Sub configuration.
  • ๐Ÿ“Š
    Interactive Results:
    Each run produces a detailed dashboard showing folding stages, RMSD calculations, ranked variant scores, etc.
  • ๐Ÿ”
    Versioned & Shareable:
    Duplicate, modify, and rerun protocols using GitHub for consistent, reproducible design studies.
Why It Matters
Protocols make it easy to
codify best practices
in your molecular design workflow โ€” reducing manual setup, improving traceability, and helping teams standardize complex AI-driven experiments.
Try It Now
Go to
Console โ†’ Protocols
to explore the built-in
AntiFold Design Antibodies
workflow or upload your own YAML blueprint to create a new one.
Run a Protocol or learn more in our help docs.

new

models

๐Ÿ†• New Models Released: TEMPRO-3B & TEMPRO-650M

๐Ÿš€ New models are live on BioLM!
Weโ€™ve just released TEMPRO-3B and TEMPRO-650M models.
  • TEMPRO-3B
    : ~3B params, high accuracy for complex tasks
  • TEMPRO-650M
    : ~650M params, lightweight & fast
Both are available now via the API and Playground. Give them a spin and let us know your feedback! ๐ŸŽ‰

new

console

๐Ÿš€ New Feature: Team Workspaces

Weโ€™re excited to announce that
Team Workspaces
are now available on BioLM for
Advanced
and
Premium
plans! ๐ŸŽ‰
With Team Workspaces, you can:
  • Keep your
    Personal Workspace
    for individual projects ๐Ÿง‘โ€๐Ÿ’ป
  • Join shared
    Team Workspaces
    with their own billing and resources ๐Ÿค
  • Organize projects inside each workspace with multiple
    Environments
    (for notebooks, volumes, protocols, and more) ๐Ÿ“‚
  • Collaborate seamlessly with colleagues in the same workspace ๐Ÿ”„
๐Ÿ’ก
Premium users
: our team can now directly collaborate with you inside your workspace โ€” co-authoring notebooks, refining protocols, and prototyping new models alongside you.
๐Ÿ‘‰ Try switching between your
Personal Workspace
and a new
Team Workspace
from the dropdown in the top navigation bar.
This is just the beginning โ€” Team Workspaces lay the foundation for deeper collaboration and resource management across BioLM.
Weโ€™d love your feedback! Drop your thoughts in the ๐Ÿ’ฌ feedback board or in our Slack community.

new

console

New Feature Release โ€“ Volumes

Weโ€™re excited to introduce ๐Ÿ“
Volumes
โ€” persistent storage you can now attach to your ๐Ÿ““ Jupyter sessions.
With Volumes you can:
  • ๐Ÿ’พ Save notebooks, data, and outputs across sessions
  • ๐Ÿ” Re-attach the same storage to multiple sessions
  • ๐Ÿ—‚๏ธ Keep everything organized in one place
And the best part? ๐ŸŽ‰
Volumes are completely free!
Give it a try in your next Jupyter session โ€” and let us know what you think.