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Changelog

Follow up on the latest improvements and updates.

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new

Workspaces in the BioLM SDK

Platform workspaces are now manageable from the BioLM CLI — list, show, and switch before you run jobs.
  • biolm workspace list
  • biolm workspace show
  • biolm workspace switch
Learn more

new

Protocols in the BioLM SDK

Protocols are YAML workflows for model runs. The SDK now covers the full loop: run on BioLM, run locally, and author your own.
  1. Run a protocol on BioLM (
    biolm protocol list
    ·
    run
    )
  2. Run a protocol locally (
    validate
    ·
    run-local
    )
  3. Create a protocol file (
    biolm protocol init
    )
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new

Run hosted models from the BioLM SDK

Call BioLM’s hosted models from the CLI with
biolm model run
— no local GPU required.
This walkthrough encodes a sequence with ESM-2 (
esm2-8m encode
).
Learn more

new

Install and authenticate with the new BioLM SDK

The new BioLM SDK is available on PyPI. Install it, then confirm your account from the terminal.
  • pip install biolm-sdk
  • biolm status
  • biolm whoami
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new

🎉 BioLM is now also open source!

You can now deploy and call BioLMs - biological language models like ESM-2, ProteinMPNN, and ESMFold - whether you're on our hosted platform or running everything yourself.
Two new repos, both fully open source under
Apache-2.0
:
  • biolm-hub
    — a standardized, agent-first catalog of open BioLMs that deploy straight into your own Modal account. Every model shares the same six actions (
    predict
    ,
    fold
    ,
    encode
    ,
    generate
    ,
    score
    ,
    log_prob
    ) and the same request/response schemas.
  • biolm-sdk
    — our new Python SDK and CLI (v1), replacing the now-deprecated
    biolm-py
    . Works against both our hosted API and your own biolm-hub gateway — switch backends with a single command, no rewritten client code. **If you're still on
    biolm-py
    , this is the time to move over.**
We also gave the docs a major refresh while we were at it.
Clone, deploy, and start serving in minutes.
🎥 Watch the walkthrough
📖 Read the full announcement
💻 Browse the repos: github.com/BioLM
📚 Read the Docs: biolm.ai/docs

new

BioLM MCP Server

BioLM now has an MCP (Model Context Protocol) server
— connect Claude, ChatGPT, or any MCP-compatible AI assistant directly to BioLM's computational biology tools. No integration code required.
Once connected, you can run protein folding, antibody design, variant effect prediction, codon optimization, toxicity screening, and more by simply describing what you want in conversation. The server exposes 20+ tools including ESMFold, ESM-1v, ABodyBuilder3, AntiFold, SADIE, DNA Chisel, Evo2, and BioLMTox-2.
Getting started:
add
https://biolm.ai/mcp
to your AI client. Supports OAuth (browser login) and API token auth. Also available as a local npm package via
npx @biolm/biolm-mcp
.
Learn more
Setup guide · Blog post

new

models

🧹 New Model: CLEAN

CLEAN is now available on BioLM: https://biolm.ai/models/clean/
This model predicts enzyme EC functions directly from sequence.
image

new

models

💧 New Model: BioLMSol

BioLMSol is now available on BioLM: https://biolm.ai/models/biolmsol/
Use this model to quickly estimate protein solubility directly from sequence.
image

new

models

🧬 New Model: BioLM-AbLEF

BioLM-AbLEF is now available on BioLM: https://biolm.ai/models/biolm-ablef/
This model analyzes antibody Fv regions and provides embeddings and developability insights for heavy/light chains.
image

new

models

🔥 New Model: ThermoMPNN

ThermoMPNN is now available on BioLM: https://biolm.ai/models/thermompnn/
Predict protein thermostability from amino acid sequence.
image
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